DHT and Male Pattern Baldness

It’s commonly accepted that the substance Dihydrotestosterone (DHT) is a major factor in androgenic alopecia (AGA), that’s male pattern hair loss to you and me. DHT is the most potent of all androgens (male sex hormones) which affects the hair growth cycle. Androgens are the driving forces in our body that determines hair distribution, including the hair on the scalp. The current theory is that DHT binds to the hair follicles, it then enters cells preventing ribonucleic acid (RNA) polymerase from functioning, RNA is key to protein synthesis. It plain English, this means if hair cells cannot create protein then hair will not grow and eventually will die.

If you want proof that androgens are involved in hair loss then you can look back through history at men who have be castrated (ouch), which is where the bollocks, sorry, I mean testicles, are removed (ouch again!). This means their body can no longer produce testosterone. These people never go bald from AGA, however when castrated males are injected with testosterone they become susceptible to baldness again. From this it is clear to conclude that testosterone plays a key role in AGA. This is probably also why women commonly don’t suffer from this type of baldness, having much lower levels of testosterone in their body.

DHT doesn’t just appear magically in the body, it occurs as the result of biological process. An enzyme called 5-alpha-reductase (5AR) converts testosterone into DHT. Testosterone is a hormone that circulates in the body and into cells, including hair follicle cells. Testosterone can also be generated in the actual follicle itself. Basically: Testosterone in hair follicles + 5a-reductase = DHT = bad news! Studies confirm that men showing signs of baldness have increased activity of 5AR in their scalps. It follows, if we can stop 5AR from working we can reduce DHT levels and prevent AGA.

There are some contentious issues here as there are two types of 5AR, Type I and Type II. Nobody is 100% sure exactly how much each enzyme contributes to DHT production that leads to baldness. The Type I enzyme is commonly found in the glands in the skin in close proximity to hair follicles, Type II is found in the dermal papillae of hair follicles, both types are found in other places around the body too.

Drugs to block 5AR have been available for a while. Finasteride (sold as Propecia) blocks the type II 5-alpha reductase reducing DHT levels by up to 60% to 70%. This has seen about one in three users regrow new hair on the crown of their heads. A Type I 5AR blocker named MK386 was tested, the results showed there was no hair regrowth in the patients who undertook the trial. It would seem clear that it is the Type II enzyme which is the problem, but another drug called Dutasteride (sold as Avodart) blocks both Type I and II. What is interesting is that Dutasteride has been shown to be some way more effective than Finasteride, even despite the fact that Type I 5AR inhibition was shown to be next to useless for hair loss.

My unsubstantiated thoughts are that the total androgenic load are a significant factor that can contribute to baldness, and by using Dutasteride you reduce both forms of the enzyme reducing total levels of DHT to lower than with just Finasteride, resulting in a lower total androgenic load. Either way it still appears Type II enzyme (in the hair follicle cell) is the main culprit, with the possibility of Type I having a smaller more limited affect. Also the fact that Type I isn’t located directly in hair cells whereas Type II is may well be a factor too ie. serum DHT levels have a minimal effect on balding compared to follicular DHT.

So it’s simple, take a load of Dutasteride and Bob’s your Uncle, right? Not quite, you should be aware that the full functions of DHT are not completely understood, for example deficiency in DHT has been linked with a risk of Alzheimer’s disease and it plays important roles in the development of male characteristics such as muscle growth and keeping other hormones such as estrogen in check. There are more than likely many other useful if not vital functions of DHT – the long term implication of blocking DHT are ambiguous. Another significant factor to consider is once you start taking the drugs you will more than likely need to take them for the rest of your life if you want to keep your hair, which is far from ideal. In forthcoming articles I will look at DHT in more detail and will try to present some ideas around the topic aimed at stopping or limiting the pesky bugger.

Watch Fifty Shades Darker (2017) Full Movie Online Streaming Online and Download

Responses to This Article

comment_type == "trackback" || $comment->comment_type == "pingback" || ereg("", $comment->comment_content) || ereg("", $comment->comment_content)) { ?>

What Other Websites Have Said About This Article

  • handsomedude said on May 8, 2012

    HEY I WANT TO KNOW WHETHER THERE IS SERIOURS CONNECTION BETWEEN MASTURBATION AND HAIRFALL PLEASE HELP ME AS I AM LOOSING HAIR AND MASTURBATING FREQUENTYLY

  • comment_type == "trackback" || $comment->comment_type == "pingback" || ereg("", $comment->comment_content) || ereg("", $comment->comment_content)) { ?>

    What Other Websites Have Said About This Article

    • leon maliniak said on July 13, 2012

      Hi Guys,

      Counter-act the negative consequences of masturbation and sexual activity on hair loss by following the principles of the MALINIAK METHOD and enjoy these activities to your heart’s content.

    • comment_type == "trackback" || $comment->comment_type == "pingback" || ereg("", $comment->comment_content) || ereg("", $comment->comment_content)) { ?>

      What Other Websites Have Said About This Article

      • leon maliniak said on July 13, 2012

        anyone who wants more information on this subject can write to me personally by using the contact us button on the website

      • comment_type == "trackback" || $comment->comment_type == "pingback" || ereg("", $comment->comment_content) || ereg("", $comment->comment_content)) { ?>

        What Other Websites Have Said About This Article

        • My Experience said on August 16, 2012

          After Reading the comment chain I feel it as my duty to tell about my experience with hair fall and mastubation.

          First of all i strongl believe that there is strong relationship between mastuabation and MPB. I am telling this on basis of my personal experience and sheer logic.

          After being in a distance relationship for over 4 months now, I started mastubation very frequently and believe fromm 4 months only I have been suffering from Intense Hair fall.

          Now talking about logic, more mastubation maens more testorone level which inturn means more DHT. Even I have the same thing advocated by many articles.

          I myself will definitely stop mastubating now and will advice you also for the same.

          Drink lots of water, aerobic exercises, green tea 2-3 times and soy seeds/ soy milk 2 times.

          Stay Healthy…..Cheers 🙂

        • comment_type == "trackback" || $comment->comment_type == "pingback" || ereg("", $comment->comment_content) || ereg("", $comment->comment_content)) { ?>

          What Other Websites Have Said About This Article

          • Rahul_dev said on September 16, 2012

            Hi Guys,
            From my personal experience I can tell that there is definitely a link between EXCESSIVE masturbation and hair loss. I am 23 and have been masturbating since I was 10, sometimes 5 times a day.
            I am going to quit masturbation, though not as easy as it sounds. I also feel better when I don’t masturbate for a few days.
            All the best guys!!!

          • comment_type == "trackback" || $comment->comment_type == "pingback" || ereg("", $comment->comment_content) || ereg("", $comment->comment_content)) { ?>

            What Other Websites Have Said About This Article

            • expert said on September 16, 2012

              ejaculation leads to increase in dht levels. so ejaculating more means more dht. avoiding masturbation will balance dht and hair follicle get rid of excessive dht. it will give more hair .

            • comment_type == "trackback" || $comment->comment_type == "pingback" || ereg("", $comment->comment_content) || ereg("", $comment->comment_content)) { ?>

              What Other Websites Have Said About This Article

              • totallyBald said on September 22, 2012

                It is surprising how all comments are talking about semen loss’ connection to hair loss while the original article is not about it at all!
                I have to agree also that semen loss seems to cause hair loss. I was already bald, but had an intact hairline. Then due to my sexual desperation or whatever I started getting frequent nocturnal emissions, very often. My baldness worsened and the hairline disappeared totally. Now the emissions have stopped but the hair is not coming back :-((

              • comment_type == "trackback" || $comment->comment_type == "pingback" || ereg("", $comment->comment_content) || ereg("", $comment->comment_content)) { ?>

                What Other Websites Have Said About This Article

                • Tony Z. said on September 30, 2012

                  I highly suspect masturbation is the cause of excess hair loss and premature balding. Some guys genes are different so they are probably more resistant to the causes of high dht levels, or there bodies break it down quicker or some other factor. Those of us who aren’t as resistant, suffer its affects more severely. I’m 19 and Ive masturbated multiple times a day since I was 13. My hairline is receded quite a bit and its very very thin on top. Being so young, and dating it definitely lowers my confidence. I’ve stayed abstinent for about 2 weeks now I will continue to do so and report back here.

                  Lets stay persistent and not loose hope.

                • comment_type == "trackback" || $comment->comment_type == "pingback" || ereg("", $comment->comment_content) || ereg("", $comment->comment_content)) { ?>

                  What Other Websites Have Said About This Article

                  • Ash said on November 2, 2012

                    Hey guys, I have been masturbating since I was 13 and now am 17, soon to turn 18. I am a life long vegetarian and a very picky eater. Since 13 I have been jerkin pretty much everyday. The first year I started doing it I’d do it 3 times a day. Then it died down to once or twice . My parents found out soon enough and they told me to stop asap. They kept telling me that I was “draining myself”. My face appeared dull and discolered and god I honestly was just so lazy during my high school years. Jerkin it def had health effects on me and until now I only thought that they were causing me deficiency problems. But now that I see these posts telling me there is a link to hair loss as well I am thinking. My hairline started to recede when I hit high school. My hairs just got so fine and in a matter of three years my temple areas are quite far back. Stress and jerkin off seriously did this to me I believe. I have not done it for around over a month now and do feel slightly more energized. I cant tell exactly the difference but there is. Atm I am waiting to see what effect will this have on my hair. I have noticed that my hair has gotten a lot more manageable but that’s all. I guess I need to play the waiting game eh. Well I will continue to hold on and see what happens. Thanks.

                  • comment_type == "trackback" || $comment->comment_type == "pingback" || ereg("", $comment->comment_content) || ereg("", $comment->comment_content)) { ?>

                    What Other Websites Have Said About This Article

                    • ankita said on December 8, 2012

                      I am a female, aged 22, and have high levels of dht in my blood due to which my hair density is very low. Please advise

                    Say Something About This Article, Go On





                    This article was written on November 22, 2005 was posted in these categories Hair Loss Causes .